Epilepsy and focal gyral anomalies detected by MRI: electroclinico-morphological correlations and follow-up.

TitoloEpilepsy and focal gyral anomalies detected by MRI: electroclinico-morphological correlations and follow-up.
Publication TypeJournal Article
Year of Publication1992
AuthorsGuerrini, R., Dravet C., Raybaud C., Roger J., Bureau M., Battaglia A., Livet M. O., Gambarelli D., and Robain O.
JournalDevelopmental medicine and child neurology
Volume34
Issue8
Pagination706-18
Date Published1992 Aug
Abstract

The authors studied 10 patients (mean age 15 years 6 months) with localized developmental gyral disorder detected by MRI. There were two groups of major malformations. Seven patients (group 1) had unilateral 'macrogyric-like' insulo-opercular changes, one of whom died early in life and had extensive microgyria. The six others had mental retardation and epilepsy, three of whom had focal neurological signs. Age at onset of epilepsy varied greatly. Clinical and EEG data suggested a wider cerebral involvement than recognized on MRI. The remaining three patients (group 2) had abnormal gyri of variable topography and extension, with bulging grey matter and ventricular deformity. One had mental retardation, another had neurological signs. All had intractable complex partial seizures and focal EEG anomalies correlating with the MRI lesion site, pointing to a well-defined epileptogenic zone. No clinical or EEG evidence of significant malformation in the remaining brain tissue was observed. Ablative surgery was beneficial for one patient; focal cortical dysplasia was the pathological substrate.

PubMed Link

http://www.ncbi.nlm.nih.gov/pubmed/1644233?dopt=Abstract

Alternate JournalDev Med Child Neurol